Kernicterusalso known as chronic bilirubin encephalopathydescribes the chronic, toxic, permanent sequelae of high levels of unconjugated bilirubin on the central nervous system of infants. It is part of the spectrum of bilirubin-induced neurologic dysfunctionwhich also includes acute bilirubin encephalopathy. Kernicterus is thought to be very rare and decreasing in incidence, although the exact incidence is unknown 1,2.
For adults, kernicterus is a matter of living with and managing disabilities. The majority of young survivors of kernicterus will become adults who continue to face varying degrees of impairment. These challenges range from mild to profound cerebral palsy, to hearing loss, to gaze abnormalities and mental retardation.
Kernicterus Bilirubin encephalopathy is an acquired metabolic encephalopathy of the neonatal period. Its etiology and pathogenesis overlap to some extent with HIE. Kernicterus is caused by unconjugated hyperbilirubinemia that develops either as a result of hemolytic disease Rh incompatibility, hereditary spherocytosis, other hemolytic disorders or because of inability of the liver to conjugate bilirubin.
Jaundice is the yellow color seen in the skin of many newborns. In some babies, the liver might not be developed enough to efficiently get rid of bilirubin. This yellow coloring is called jaundice. When severe jaundice goes untreated for too long, it can cause a condition called kernicterus.
When a newborn begins to display signs of kernicterus, brain damage is starting to occur. Kernicterus is a medical emergency due to its rapid development, even in apparently healthy newborns. As experienced kernicterus lawyers, we fully understand the tie between prompt medical intervention and the prevention of needless brain damage.
Kernicterus is a rare neurological disorder characterized by excessive levels of bilirubin in the blood hyperbilirubinemia during infancy. Bilirubin is an orange-yellow bile pigment that is a byproduct of the natural breakdown of hemoglobin in red blood cells hemolysis. Toxic levels of bilirubin may accumulate in the brain, potentially resulting in a variety of symptoms and physical findings.
Kernicterus is a bilirubin -induced brain dysfunction. The term was coined in by Schmorl. Bilirubin is a naturally occurring substance in the body of humans and many other animals, but it is neurotoxic when its concentration in the blood is too high, a condition known as hyperbilirubinemia.
In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin a yellow pigment in the blood—a condition called hyperbilirubinemia. Bilirubin is formed when hemoglobin the part of red blood cells that carries oxygen is broken down as part of the normal process of recycling old or damaged red blood cells.
Bilirubin encephalopathy is a rare neurological condition that occurs in some newborns with severe jaundice. Bilirubin encephalopathy BE is caused by very high levels of bilirubin. Bilirubin is a yellow pigment that is created as the body gets rid of old red blood cells.